Endocrine Abstracts

Background: Acetyl-CoA-Carboxylase (ACC1), the rate-limiting enzyme of de novo lipogenesis, plays a critical role in beta cell growth and insulin secretion. In spite of plethora evidence for the role of ACC1 in insulin secretion and beta cells function both in vivo and in vitro, very little is known about how ACC1 activity is regulated in pancreatic beta cells. The aim of the current study was to screen for novel phospho-sites that may regulate ACC1 activity ...

Backgrounds and aims: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. The somatostatin (SST)-producing D-cell is an EEC of particular interest due to the profound inhibition exerted by SST over other EECs, highlighting D-cells as critical regulator of the enteroendocrine axis. The aim of this study was to profile the transcriptom...

The majority of the body’s 5-HT (serotonin) is produced from enterochromaffin cells (ECs) of the intestinal epithelium. 5-HT has important roles within the gastrointestinal tract in the modulation of motility, secretion and inflammation, while also signalling satiety and discomfort to the central nervous system. The factors regulating release of 5-HT from human small intestinal ECs have not been clearly elucidated: although circulating 5-HT levels typically increase after...